Description

2-Oxo-2,4-Dihydro-1H-Benzo[D][1,3]Oxazine-6-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a key building block in modern organic synthesis. This compound is specifically engineered to facilitate efficient cross-coupling reactions, enabling the construction of complex molecular architectures with precision. It is an essential reagent for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality boronic ester derivatives for Suzuki-Miyaura and other palladium-catalyzed coupling methodologies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates containing the benzoxazine scaffold.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds, essential for creating complex organic molecules.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of targeted compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring functionalized benzoxazine derivatives.

Basic Information

Product Name	2-Oxo-2,4-Dihydro-1H-Benzo[D][1,3]Oxazine-6-Boronic Acid Pinacol Ester
CAS No.	1421341-04-9
Molecular Formula	C15H18BNO4
Molecular Weight	287.12 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine-2,4-dione; 2-Oxo-3,4-dihydro-2H-1,3-benzoxazine-6-boronic acid pinacol ester; Benzoxazine-6-boronic acid pinacol ester; CAS 1421341-04-9; 6-BPin Benzoxazinone
EINECS	Contact for details

Quality Control

Our 2-Oxo-2,4-Dihydro-1H-Benzo[D][1,3]Oxazine-6-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.