Description

5-Nitro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-value, protected boronic acid derivative, specifically an aniline-substituted pinacol boronate ester. This compound serves as a critical synthetic intermediate, prized for its stability and reactivity in cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex aromatic amine scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing biphenyl or heterobiaryl amine structures.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, enabling the introduction of nitro-aniline pharmacophores.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as conductive polymers and OLED components.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the synthesis of activity-based probes targeting amine-reactive sites.
• Academic & R&D Laboratories: Fundamental reagent for methodological development in organoboron chemistry and catalysis studies.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring a protected, functional-group-rich boronic ester precursor.

Basic Information

Product Name	5-Nitro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1421322-60-2
Molecular Formula	C12H17BN2O4
Molecular Weight	264.09 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-nitroaniline; 5-Nitro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 2-Amino-4-nitrophenylboronic acid pinacol ester; (5-Nitro-2-aminophenyl)boronic acid pinacol ester; 5-Nitro-2-aminophenylboronic acid pinacol ester; 1421322-60-2; Boronic acid, B-(2-amino-4-nitrophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-Nitro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive analytical data including HPLC purity, NMR (¹H, ¹³C, ¹¹B), and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.