Description

4-Amino-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-value, multifunctional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex molecular architectures with precision. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery, catalyst development, and organic electronic material synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling reactions.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic semiconductors, OLED materials, and conductive polymers.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of molecular probes and sensors.
• Catalyst Ligand Development: Utilized to synthesize novel bidentate or monodentate ligands for transition metal catalysis.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	4-Amino-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1421322-57-7
Molecular Formula	C₁₃H₁₇BN₂O₂
Molecular Weight	244.10 g/mol
Synonyms	2-Amino-4-cyanophenylboronic acid pinacol ester; 4-Cyano-2-aminophenylboronic acid pinacol ester; 2-Amino-4-cyanobenzene-1-boronic acid pinacol ester; (4-Cyano-2-aminophenyl)boronic acid pinacol ester; 4-Amino-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-aminobenzonitrile; PINACOL 4-AMINO-2-BORONOBENZONITRILE; 4-Amino-2-boronobenzonitrile pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Amino-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.