Description

3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indazole is a high-value, protected indazole boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in advanced organic synthesis. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials. The CAS number for this compound is 1421252-90-5.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Precursor for creating organic electronic materials, such as OLEDs and organic semiconductors, via polymerization or functionalization.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker in bioconjugation and target identification studies.
• Academic & Contract Research: A versatile reagent for methodological development and complex molecule construction in university and CRO laboratories.
• Scale-up Process Development: Serves as a reliable intermediate for optimizing and scaling synthetic routes from milligram to kilogram scale.

Basic Information

Item	Detail
Product Name	3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indazole
CAS No.	1421252-90-5
Molecular Formula	C22H27BN2O4S
Molecular Weight	426.34 g/mol
Synonyms	1H-Indazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-, 3,5-dimethyl-; 3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-tolylsulfonyl)-1H-indazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-3,5-dimethyl-1H-indazole; 3,5-Dimethyl-1-tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1-Tosyl-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole; Pinacol 3,5-dimethyl-1-tosyl-1H-indazole-4-boronate
EINECS	Contact for details

Quality Control

Our 3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.