Description

2,4-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value organoboron building block, specifically a pyridine-substituted pinacol boronic ester. This compound is a critical intermediate in modern synthetic chemistry, enabling the precise construction of complex molecular architectures. It is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and medicinal chemistry.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to construct biaryl and heterobiaryl systems, essential in pharmaceutical and agrochemical active ingredient synthesis.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly for creating complex pyridine-containing scaffolds.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with pyridine-based structures.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Utilized in the creation of organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Acts as a versatile linker or functional group in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Product Name	2,4-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1421252-89-2
Molecular Formula	C13H20BNO2
Molecular Weight	233.11 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dimethylpyridine; 2,4-Dimethyl-3-pyridineboronic acid pinacol ester; (2,4-Dimethylpyridin-3-yl)boronic acid pinacol ester; 3-Borono-2,4-dimethylpyridine pinacol ester; 2,4-Dimethyl-3-pyridinylboronic acid pinacol ester; Pinacol (2,4-dimethyl-3-pyridinyl)boronate; 2,4-Dimethyl-3-(pinacolatoboryl)pyridine
EINECS	Contact for details

Quality Control

Our 2,4-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.