Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[(1E)-2-(3-Methylphenyl)Ethenyl]- is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is valued for its role as a key coupling partner in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical reagent for forming carbon-carbon bonds between aryl/vinyl halides and this boronic ester, widely used in pharmaceutical intermediate synthesis.
• Pharmaceutical Research & Development: Serves as a versatile building block for creating complex, drug-like scaffolds and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, light-emitting materials, and other functional polymers.
• Chemical Biology & Probe Development: Useful for tagging and modifying biomolecules or creating molecular probes for diagnostic applications.
• Scale-up Process Chemistry: Suitable for transition from laboratory-scale research to pilot plant and commercial manufacturing due to its defined reactivity and stability profile.

Basic Information

Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[(1E)-2-(3-Methylphenyl)Ethenyl]-
CAS No.	1421061-31-5
Molecular Formula	C15H21BO2
Molecular Weight	244.14 g/mol
Synonyms	2-[(E)-2-(3-Methylphenyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-2-(2-(3-Methylphenyl)vinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methylstyrylboronic acid pinacol ester; (E)-3-Methylstyrylboronic Acid Pinacol Ester; trans-3-Methylstyrylboronic Acid Pinacol Ester; 4,4,5,5-Tetramethyl-2-[(E)-2-(m-tolyl)ethenyl]-1,3,2-dioxaborolane; Pinacol (E)-3-Methylstyrylboronate
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[(1E)-2-(3-Methylphenyl)Ethenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z ratio by HPLC)	≥ 98:2 (E:Z)
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.