Description

Benzamide,3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-[4-(Trifluoromethyl)-2-Pyridinyl]- is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic ester pinacol group and a trifluoromethylpyridine moiety. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in pharmaceutical R&D and agrochemical synthesis who require reliable, high-quality precursors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester functionality makes this compound a versatile coupling partner for creating carbon-carbon bonds between aromatic rings, essential for constructing drug-like molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl and fluorine groups can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its conjugated aromatic system.
• Chemical Biology Probe Development: Utilized in creating labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clinical trials.

Basic Information

Product Name	Benzamide,3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-[4-(Trifluoromethyl)-2-Pyridinyl]-
CAS No.	1419221-60-5
Molecular Formula	C19H19BF4N2O3
Molecular Weight	410.17 g/mol
Synonyms	3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide; 2-Pyridinecarboxamide, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[4-(trifluoromethyl)-2-pyridinyl]-; 1419221-60-5; (3-Fluoro-4-((4-(trifluoromethyl)pyridin-2-yl)carbamoyl)phenyl)boronic acid pinacol ester; Boronic acid, B-[3-fluoro-4-[[[4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of Benzamide,3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-[4-(Trifluoromethyl)-2-Pyridinyl]- is manufactured under strict quality management systems. Our products undergo rigorous quality testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request for every shipment, providing full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.