Description

Di-tert-Butyl 4,4'-(Disulfanediylbis(Methylene))Bis(Piperidine-1-Carboxylate) is a specialized organic compound featuring a disulfide-linked bis(piperidine) core, serving as a critical building block in advanced chemical synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially those targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker component to connect E3 ligase ligands with target protein ligands, enabling targeted protein degradation.
• Chemical Biology Research: Employed in the development of molecular probes and tools to study enzyme function and protein-protein interactions.
• Peptidomimetic Synthesis: Serves as a rigid, disulfide-containing scaffold for creating stable peptide analogs with enhanced metabolic stability.
• Polymer Chemistry: Can be utilized as a cross-linking agent or monomer for synthesizing specialty polymers with unique redox-responsive properties.
• Agrochemical Research: Intermediate in the development of new crop protection agents and pesticides with novel modes of action.

Basic Information

Product Name	Di-tert-Butyl 4,4'-(Disulfanediylbis(Methylene))Bis(Piperidine-1-Carboxylate)
CAS No.	1417793-96-4
Molecular Formula	C22H40N2O4S2
Molecular Weight	460.68 g/mol
Synonyms	Di-tert-butyl 4,4'-(disulfanediyldimethylene)dipiperidine-1-carboxylate; 1,1'-[Dithiobis(methylene)]bis[4-piperidinecarboxylic acid] di-tert-butyl ester; Bis(1-Boc-4-piperidinylmethyl) disulfide; Di-tert-butyl 4,4'-(disulfanediylbis(methylene))bis(piperidine-1-carboxylate); 1,1'-[Disulfanediylbis(methylene)]bis[piperidine-4-carboxylic acid] di-tert-butyl ester; (Boc-piperidin-4-ylmethyl) disulfide; DiBoc-protected bis(piperidinylmethyl) disulfide; CAS 1417793-96-4
EINECS	Contact for details

Quality Control

Our Di-tert-Butyl 4,4'-(Disulfanediylbis(Methylene))Bis(Piperidine-1-Carboxylate) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D applications. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H NMR, ¹³C NMR)
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.