Description

2-Bromo-1,3-Difluoro-5-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated benzene derivative designed for advanced chemical synthesis. This compound serves as a critical building block in the development of complex molecules, offering unique reactivity due to its specific pattern of bromo, fluoro, and trifluoromethoxy substituents. It is primarily utilized by R&D and production chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and thermal stability.
• Polymer & Resin Modification: Employed to introduce fluorine atoms into polymer backbones or side chains, enhancing chemical resistance, lowering surface energy, and improving material performance.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating novel chemical entities in academic and industrial R&D settings.

Basic Information

Product Name	2-Bromo-1,3-Difluoro-5-(Trifluoromethoxy)Benzene
CAS No.	1417568-00-3
Molecular Formula	C7H2BrF5O
Molecular Weight	276.99 g/mol
Synonyms	1-Bromo-2,4-difluoro-6-(trifluoromethoxy)benzene; 2,4-Difluoro-6-(trifluoromethoxy)bromobenzene; 2-Bromo-1,3-difluoro-5-(trifluoromethoxy)benzene; 5-(Trifluoromethoxy)-2-bromo-1,3-difluorobenzene; Benzene, 2-bromo-1,3-difluoro-5-(trifluoromethoxy)-; 1417568-00-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-1,3-Difluoro-5-(Trifluoromethoxy)Benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, GC for residual solvents, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.