Description

2-Fluoro-1-(Trifluoromethoxy)-3-(Trifluoromethyl)Benzene is a high-purity, multi-fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both trifluoromethoxy and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is essential for R&D and production within the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine motifs contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Material Science: Acts as a monomer or modifier for creating high-performance, fluorinated polymers with exceptional chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, value-added fluorinated compounds.

Basic Information

Product Name	2-Fluoro-1-(Trifluoromethoxy)-3-(Trifluoromethyl)Benzene
CAS No.	1417567-37-3
Molecular Formula	C9H3F7O
Molecular Weight	260.11 g/mol
Synonyms	1-(Trifluoromethoxy)-2-fluoro-3-(trifluoromethyl)benzene; 2-Fluoro-α,α,α-trifluoro-3-(trifluoromethyl)anisole; 3-(Trifluoromethyl)-2-fluoro-1-(trifluoromethoxy)benzene; Benzene, 2-fluoro-1-(trifluoromethoxy)-3-(trifluoromethyl)-; 2-Fluoro-1-(trifluoromethoxy)-3-(trifluoromethyl)benzene; F-TFMB (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-1-(Trifluoromethoxy)-3-(Trifluoromethyl)Benzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical characterization including GC, HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with each shipment to ensure it meets your precise research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Due to its highly volatile nature, ensure containers are kept tightly sealed at temperatures between 15-25°C to prevent loss and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Purity (GC/HPLC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.