Description

3-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbaldehyde is a high-purity, multifunctional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the strategic combination of a reactive aldehyde group and a protected boronic acid moiety, enabling sequential cross-coupling and functionalization reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise intermediates for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The tetramethyl dioxaborolane (pinacol boronic ester) group acts as a stable, protected handle for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides containing fluorinated pyridine cores.
• Ligand and Catalyst Development: Serves as a starting material for creating novel bidentate ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the construction of organic electronic materials, such as OLED emitters and charge-transport molecules.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags and molecular probes for bio-conjugation and imaging applications.

Basic Information

Product Name	3-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbaldehyde
CAS No.	1417200-18-0
Molecular Formula	C12H15BFNO3
Molecular Weight	251.06 g/mol
Synonyms	2-Formyl-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluoropyridine-2-carboxaldehyde; 3-Fluoro-5-(pinacolatoboryl)picolinaldehyde; 3-Fluoro-5-(pinacolboronato)picolinaldehyde; 3-Fluoro-5-(pinacolboryl)pyridine-2-carbaldehyde; 3-Fluoro-5-(pinacolatoboron)picolinaldehyde
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light may affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.