Description

3-Formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a high-value, multi-functional organic building block that combines a formyl group, a nitrile group, and a protected boronic ester moiety on a benzene ring. This unique structure makes it a critical intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl and heterobiaryl scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Key building block for constructing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biaryl structures.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLEDs and organic semiconductors, where conjugated systems are essential.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate or tridentate ligands for catalysis.
• Chemical Biology Probes: Useful for creating tagged molecules or bioconjugates for biological target identification and study.
• Academic & Contract Research: A versatile reagent for methodology development and synthetic chemistry research in academic and CRO laboratories.

Basic Information

Product Name	3-Formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
CAS No.	1417200-10-2
Molecular Formula	C14H16BNO3
Molecular Weight	257.10 g/mol
Synonyms	5-Cyano-3-formylphenylboronic acid pinacol ester; 3-Cyano-5-formylphenylboronic acid pinacol ester; (3-Cyano-5-formylphenyl)boronic acid pinacol ester; 5-Formyl-3-cyanophenylboronic acid pinacol ester; 3-Formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 1417200-10-2; PINACOL 3-CYANO-5-FORMYLPHENYLBORONATE
EINECS	Contact for details

Quality Control

Our 3-Formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.