Description

1-[2-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Ethanone is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate. Its primary value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex aryl-aryl bonds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific biphenyl or heterocyclic motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where controlled conjugation is vital.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized to synthesize molecular probes and tags for studying biological processes and target engagement.
• Custom Fine Chemical Production: A versatile reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke organic compounds.

Basic Information

Product Name	1-[2-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Ethanone
CAS No.	1417036-29-3
Molecular Formula	C15H21BO3
Molecular Weight	260.14 g/mol
Synonyms	2-Methyl-4-acetylphenylboronic acid pinacol ester; 1-(2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one; 4-Acetyl-3-methylphenylboronic acid pinacol ester; 2-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)acetophenone; Pinacol [4-acetyl-3-methylphenyl]boronate; 4-Acetyl-2-methylbenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1-[2-Methyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Ethanone adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.