Description

2-Chloro-4-Formylpyridine-5-Boronic Acid Pinacol Ester is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. This compound, with CAS number 1416721-79-3, is prized for its dual reactivity, featuring both a formyl group and a protected boronic acid moiety, enabling efficient cross-coupling and subsequent functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl scaffolds found in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Material Science Research: Serves as a building block for creating organic ligands in catalysis or functional organic materials.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and target engagement.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Provides a reliable and pure starting material for optimizing synthetic routes from milligram to kilogram scale.

Basic Information

Product Name	2-Chloro-4-Formylpyridine-5-Boronic Acid Pinacol Ester
CAS No.	1416721-79-3
Molecular Formula	C₁₃H₁₅BClNO₃
Molecular Weight	279.52 g/mol
Synonyms	5-Formyl-2-chloropyridine-3-boronic acid pinacol ester; (5-Formyl-2-chloropyridin-3-yl)boronic acid pinacol ester; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinaldehyde; 3-Formyl-6-chloropyridine-5-boronic acid pinacol ester; 1416721-79-3; 2-Chloro-4-formylpyridine-5-boronic acid pinacol ester; 2-Chloro-4-formylpyridin-5-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Formylpyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency suitable for demanding research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.