Description

Pyrazolo[1,5-A]Pyrimidine-6-Boronic Acid Pinacol Ester is a high-value boronic acid derivative and a key synthetic building block in modern organic chemistry. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for methodological development and library synthesis in academic and CRO laboratory settings.
• Custom Synthesis: Used for the bespoke production of complex, boronic acid-functionalized molecules for specialized applications.

Basic Information

Product Name	Pyrazolo[1,5-A]Pyrimidine-6-Boronic Acid Pinacol Ester
CAS No.	1416437-27-8
Molecular Formula	C13H18BN3O2
Molecular Weight	259.11 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a]pyrimidin-6-ylboronic acid pinacol ester; 6-(Pinacolatoboryl)pyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a]pyrimidine-6-boronic acid pinacol ester; 1416437-27-8; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[1,5-a]pyrimidine; Boronic acid, B-(pyrazolo[1,5-a]pyrimidin-6-yl)-, pinacol ester.
EINECS	Contact for details

Quality Control

Our Pyrazolo[1,5-A]Pyrimidine-6-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.