Description

3-(1,1-Dioxido-2-Isothiazolidinyl)Phenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a key building block in modern organic synthesis. This compound is specifically engineered for applications requiring precise molecular coupling, offering exceptional reactivity and selectivity in cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, essential for constructing complex biaryl structures in drug discovery.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing the sulfonamide (dioxido-isothiazolidinyl) pharmacophore.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aryl-boronate functionalities.
• Material Science & OLED Development: Employed in the creation of organic electronic materials, including charge-transport layers and emissive materials for OLED displays and lighting.
• Chemical Biology & Probe Development: Utilized as a building block for creating molecular probes and bioconjugates used in diagnostic assays and biochemical research.
• Library Synthesis for High-Throughput Screening: A valuable scaffold for generating diverse compound libraries in medicinal chemistry programs to identify new drug candidates.

Basic Information

Product Name	3-(1,1-Dioxido-2-Isothiazolidinyl)Phenylboronic Acid Pinacol Ester
CAS No.	1416367-18-4
Molecular Formula	C15H20BNO4S
Molecular Weight	321.20 g/mol
Synonyms	3-(1,1-Dioxido-1,2-thiazolidin-2-yl)phenylboronic acid pinacol ester; 2-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,2-thiazolidine 1,1-dioxide; 3-(1,1-Dioxido-2-isothiazolidinyl)benzeneboronic acid pinacol ester; [3-(1,1-Dioxido-1,2-thiazolidin-2-yl)phenyl]boronic acid pinacol ester; Boronic acid, B-[3-(1,1-dioxide-2-isothiazolidinyl)phenyl]-, pinacol ester; 3-(1,1-Dioxido-2-isothiazolidinyl)phenylboronic acid neopentyl glycol ester (common alternative); Sulfone-containing arylboronic ester
EINECS	Contact for details

Quality Control

Our 3-(1,1-Dioxido-2-Isothiazolidinyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.