Description

2-(3-Ethoxy-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly those containing fluorinated biaryl structures.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorinated phenyl moiety can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated organic semiconductors and liquid crystal compounds used in display technologies.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and functional materials with tailored electronic or optical properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries.
• Fluorine Chemistry: Acts as a protected form of a fluorinated aryl boronic acid, facilitating handling and storage in complex multi-step syntheses.

Basic Information

Product Name	2-(3-Ethoxy-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1416367-03-7
Molecular Formula	C14H20BFO3
Molecular Weight	266.12 g/mol
Synonyms	(3-Ethoxy-5-fluorophenyl)boronic acid pinacol ester; 5-Fluoro-3-ethoxyphenylboronic acid pinacol ester; 3-Ethoxy-5-fluorobenzeneboronic acid pinacol ester; 2-(3-Ethoxy-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-ethoxy-5-fluorophenyl)boronate; 3-Ethoxy-5-fluorophenyl-Bpin; 1416367-03-7; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 2-(3-Ethoxy-5-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with internal quality standards and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.