Description

[2-Fluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Acetic Acid Methyl Ester is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to create novel, fluorinated herbicides, fungicides, and insecticides with enhanced biological activity and environmental stability.
• Material Science Research: Building block for developing organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, where the fluorine atom and boronate ester group fine-tune electronic properties.
• Ligand & Catalyst Development: Intermediate for synthesizing sophisticated ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and tags for studying biological processes and protein interactions.
• Custom & Contract Synthesis: Supplied to CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and development projects.

Basic Information

Product Name	[2-Fluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Acetic Acid Methyl Ester
CAS No.	1415960-53-0
Molecular Formula	C15H20BFO4
Molecular Weight	294.13 g/mol
Synonyms	Methyl 2-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylacetic acid methyl ester; Methyl (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate; 2-Fluoro-4-(pinacolatoboron)benzeneacetic acid methyl ester; 1415960-53-0; [2-Fluoro-4-(pinacolboron)phenyl]acetic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of our [2-Fluoro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Acetic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions and advanced research. A detailed Certificate of Analysis (COA) including results for assay, purity (HPLC), and identity confirmation is supplied with each shipment, ensuring full traceability and reliable batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.