Description

Methyl 1-[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane carboxylate ester and a protected boronic acid ester (pinacol boronate) functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biaryl or heterobiaryl motifs for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the incorporated fluorophenyl and cyclopropane groups can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for diagnostic assays and biomedical imaging research.
• Cross-Coupling Reactions: Primarily designed as a robust, air-stable boronate ester reagent for efficient palladium-catalyzed Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides or triflates.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) and R&D laboratories for custom synthesis projects and process development.

Basic Information

Item	Details
Product Name	Methyl 1-[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxylate
CAS No.	1415960-52-9
Molecular Formula	C17H22BFO4
Molecular Weight	320.17 g/mol
Synonyms	1-[2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylic acid methyl ester; Methyl 1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylate; 2-Fluoro-4-(1-methoxycarbonylcyclopropyl)phenylboronic acid pinacol ester; (2-Fluoro-4-(1-(methoxycarbonyl)cyclopropyl)phenyl)boronic acid pinacol ester; CAS 1415960-52-9; Boronic ester intermediate 1415960-52-9
EINECS	Contact for details

Quality Control

Every batch of Methyl 1-[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Cyclopropane-1-Carboxylate is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring the material meets the stringent requirements for advanced synthetic applications. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.