Description

(2-Amino-3,5-Difluorophenyl)Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. Its value lies in its role as a protected boronic acid derivative, offering enhanced stability and handling characteristics for critical coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A crucial reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in drug discovery.
• Pharmaceutical Intermediate: Serves as a key building block in the research and production of active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Agrochemical Synthesis: Used in the development of new generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for catalysis and organometallic complexes.
• Material Science Research: A precursor for creating organic electronic materials, such as those used in OLEDs and sensors.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	(2-Amino-3,5-Difluorophenyl)Boronic Acid Pinacol Ester
CAS No.	1415568-78-3
Molecular Formula	C₁₂H₁₆BF₂NO₂
Molecular Weight	255.07 g/mol
Synonyms	2-Amino-3,5-difluorophenylboronic acid pinacol ester; 3,5-Difluoro-2-aminophenylboronic acid pinacol ester; (2-Amino-3,5-difluorophenyl)boronic acid, pinacol ester; 4,4,5,5-Tetramethyl-2-(2-amino-3,5-difluorophenyl)-1,3,2-dioxaborolane; 2-(2-Amino-3,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-(2-amino-3,5-difluorophenyl)-, 1,1-dimethylethyl ester (9CI); B-(2-Amino-3,5-difluorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our (2-Amino-3,5-Difluorophenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.