Description

Benzo[B]Thiophene, 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value boronic ester derivative, a key synthetic intermediate in modern organic chemistry. Its primary commercial value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in the development of thiophene-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the benzo[b]thiophene core is advantageous.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl systems.
• Chemical Library Development: Employed in medicinal and combinatorial chemistry for the rapid generation of diverse compound libraries for high-throughput screening.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	Benzo[B]Thiophene, 2,3-Dihydro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1415468-76-6
Molecular Formula	C16H21BO2S
Molecular Weight	288.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1-benzothiophene; 2,3-Dihydrobenzo[b]thiophen-5-ylboronic acid pinacol ester; 2,3-Dihydro-1-benzothiophene-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrobenzo[b]thiophene; Dihydrobenzo[b]thiophene-5-boronic acid pinacol ester; Benzo[b]thiophene-5-boronic acid, 2,3-dihydro-, pinacol ester; 5-Pinacolatoboryl-2,3-dihydrobenzo[b]thiophene
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor quality documentation to meet specific regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.