Description

Ald-Peg4-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal aldehyde group protected as a tert-butyl ester. This molecular design is critical for providing a stable, reactive handle for bioconjugation and polymer modification under controlled conditions. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotech sectors who require precise and reliable linkers for drug delivery systems, peptide synthesis, and surface functionalization.

Application

• Bioconjugation & Drug Delivery: Serves as a key linker for attaching therapeutic payloads (e.g., drugs, toxins, imaging agents) to antibodies, proteins, or nanoparticles, enabling targeted delivery.
• Peptide & Protein Modification: Used to introduce PEG chains (PEGylation) onto peptides or proteins to enhance solubility, stability, and circulation half-life.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for synthesizing advanced hydrogels, smart polymers, and functionalized surfaces.
• Diagnostic Reagent Synthesis: Employed in the development of diagnostic assays and probes where a stable, cleavable, or reactive linker is required.
• Click Chemistry & Organic Synthesis: Provides a protected aldehyde functionality for subsequent chemical transformations in multi-step synthetic routes.

Basic Information

Product Name	Ald-Peg4-T-Butyl Ester
CAS No.	1415329-20-2
Molecular Formula	C21H40O9
Molecular Weight	436.54 g/mol
Synonyms	1-Aza-2-oxo-15,19,23,27-tetraoxa-3,18,22,26-tetraoxanonacos-28-en-29-oic acid, 1,1-dimethylethyl ester; t-Butyl-PEG4-aldehyde; 4,7,10,13-Tetraoxa-16-azahenicos-20-en-1-oic acid, 21-oxo-, 1,1-dimethylethyl ester; Aldehyde-PEG4-t-butyl ester; tert-Butyl 3-oxo-2,5,8,11,14-pentaoxa-4-azahexadecan-16-oate; Fmoc-PEG4-CHO t-butyl ester (protected precursor); PEG4 spacer t-butyl aldehyde ester
EINECS	Contact for details

Quality Control

Our Ald-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.