Description

5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)-1,3-Thiazole is a high-value, organoboron building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex molecules containing the 2-(trifluoromethyl)-1,3-thiazole pharmacophore, a privileged scaffold in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting infectious diseases, oncology, and central nervous system disorders.
• Agrochemical Research: Used to create advanced active ingredients for crop protection agents, leveraging the bioactivity of the thiazole and trifluoromethyl groups.
• Material Science: Serves as a precursor for synthesizing functionalized polymers or organic electronic materials with specific optoelectronic properties.
• Chemical Biology: Employed in the development of molecular probes and bioconjugation tools to study biological processes and protein interactions.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Process Chemistry: Used in route scouting and optimization for the scalable production of complex target molecules under robust conditions.

Basic Information

Item	Detail
Product Name	5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)-1,3-Thiazole
CAS No.	1415241-98-3
Molecular Formula	C10H13BF3NO2S
Molecular Weight	279.09 g/mol
Synonyms	2-(Trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 2-(Trifluoromethyl)thiazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)thiazole; 2-Trifluoromethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Thiazole-5-boronic acid, 2-(trifluoromethyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)-1,3-Thiazole is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency for reliable research and development outcomes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.