Description

1-Bromo-2-Cyclopropyl-3-Fluorobenzene is a high-purity, multi-functional halogenated aromatic building block designed for advanced synthetic chemistry. This compound is engineered to provide reliable reactivity and structural diversity for the development of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, ligand synthesis, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the cyclopropyl and fluorine motifs for enhanced bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, enabling the rapid construction of complex biaryl and heterocyclic systems.
• Medicinal Chemistry SAR Studies: Facilitates structure-activity relationship (SAR) exploration by allowing systematic variation around the halogen and cyclopropyl positions.
• Ligand and Catalyst Development: Employed in the synthesis of novel phosphine, N-heterocyclic carbene (NHC), and other specialty ligands for catalysis.

Basic Information

Product Name	1-Bromo-2-Cyclopropyl-3-Fluorobenzene
CAS No.	1415096-07-9
Molecular Formula	C9H8BrF
Molecular Weight	215.06 g/mol
Synonyms	2-Bromo-1-Cyclopropyl-3-Fluorobenzene; 3-Fluoro-2-Cyclopropylbromobenzene; 1-Bromo-2-Cyclopropyl-3-Fluorobenzene; 2-Cyclopropyl-3-Fluorobromobenzene; (2-Bromo-6-fluorophenyl)cyclopropane; Benzene, 1-bromo-2-cyclopropyl-3-fluoro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Cyclopropyl-3-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.