Description

tert-Butyl (2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a pinacol boronate ester functional group. This compound matters as a critical building block for the synthesis of complex molecules, enabling key carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in oncology and antiviral research.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a crucial coupling partner for constructing biaryl and heterobiaryl structures central to many modern pharmaceuticals.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group protects the amine functionality during multi-step synthetic sequences, allowing for selective deprotection later.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of lead compounds.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Chemical Biology Probes: Can be utilized to create labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl (2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)carbamate
CAS No.	1414475-01-6
Molecular Formula	C16H28BN3O4
Molecular Weight	337.23 g/mol
Synonyms	1H-Pyrazole-1-ethanamine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, N-BOC derivative; tert-Butyl N-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]ethyl]carbamate; BOC-Protected 4-(Pinacolboryl)pyrazole Ethylamine; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-amine, Boc-protected; 4-Pinacolatoboryl-1H-pyrazole-1-ethylamine BOC derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl (2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.