Description

2,4-Difluoro-5-Formylphenylboronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a boronic acid moiety on a difluorinated aromatic ring, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the fluorine atoms for enhanced metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the production of organic electronic materials, such as OLEDs and OFETs, where the difluoro and formyl groups tune electronic properties.
• Chemical Biology & Proteomics: Utilized as a handle for bioconjugation and in the development of activity-based probes and sensors.
• Custom Synthesis & Contract Research: A vital reagent for CROs and CDMOs offering bespoke chemical synthesis services to global clients.

Basic Information

Product Name	2,4-Difluoro-5-Formylphenylboronic Acid
CAS No.	1413393-42-6
Molecular Formula	C7H5BF2O3
Molecular Weight	185.92 g/mol
Synonyms	(5-Formyl-2,4-difluorophenyl)boronic acid; 2,4-Difluoro-5-formylbenzeneboronic acid; 5-Borono-2,4-difluorobenzaldehyde; 2,4-Difluorobenzaldehyde-5-boronic acid; (2,4-Difluoro-5-formylphenyl)boronic acid; DFBPBA; CAS 1413393-42-6
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Formylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA), including results for purity (HPLC), identity (NMR, IR), and specific impurity profiles, is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.