Description

3-Fluoroazetidine-1-Sulfonyl Chloride is a high-value, reactive organofluorine building block used in advanced organic synthesis. This compound is particularly significant for its role as a key sulfonylation reagent, enabling the efficient introduction of the sulfonamide functional group into complex molecular architectures. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including protease inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A critical reagent for synthesizing sulfonamide-based drug candidates, including potential treatments for cancer, viral infections, and metabolic diseases.
• Protease Inhibitor Development: Used to construct the sulfonamide moiety found in many potent inhibitors of enzymes like thrombin, factor Xa, and viral proteases.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) and affinity labels to study enzyme function and mechanism.
• Material Science Research: Investigated as a monomer or cross-linking agent for the synthesis of specialty polymers with unique surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial research quantities.

Basic Information

Product Name	3-Fluoroazetidine-1-Sulfonyl Chloride
CAS No.	1411940-38-9
Molecular Formula	C3H5ClFNO2S
Molecular Weight	173.59 g/mol
Synonyms	1-(Chlorosulfonyl)-3-fluoroazetidine; 3-Fluoro-1-azetidinesulfonyl chloride; 3-Fluoroazetidine-1-sulfonyl chloride; 3-Fluoroazetidine sulfonyl chloride; Azetidine, 3-fluoro-, 1-sulfonyl chloride; 3-Fluoroazetidine-1-sulfonic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoroazetidine-1-Sulfonyl Chloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are designed to meet the exacting requirements of research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and safety parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) and allowed to reach room temperature before opening to prevent moisture ingress. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.