Description

5-Chloro-2-(Pivaloylamino)Phenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a protected boronic acid derivative. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry and materials science. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex, functionalized biaryl structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: A protected, air-stable boronate ester used in palladium-catalyzed carbon-carbon bond formation for constructing complex organic molecules.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides requiring specific chlorinated and aminated aromatic frameworks.
• Material Science Research: Used in the creation of organic electronic materials, ligands for catalysts, and novel polymers.
• Chemical Biology & Proteomics: Potential building block for creating molecular probes and inhibitors for biological target identification.
• Custom Synthesis & Contract Manufacturing: Sourced by CROs and CMOs for client projects requiring specific, high-value boronic acid derivatives.

Basic Information

Product Name	5-Chloro-2-(Pivaloylamino)Phenylboronic Acid Pinacol Ester
CAS No.	1409999-52-5
Molecular Formula	C₁₇H₂₅BClNO₃
Molecular Weight	337.65 g/mol
Synonyms	5-Chloro-2-[(2,2-dimethylpropanoyl)amino]phenylboronic acid pinacol ester; 2-Amino-5-chlorophenylboronic acid pinacol ester, N-Pivaloyl derivative; (5-Chloro-2-(pivalamido)phenyl)boronic acid pinacol ester; B-[5-Chloro-2-[(2,2-dimethyl-1-oxopropyl)amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1409999-52-5; N-(5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pivalamide
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-(Pivaloylamino)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.