Description

6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Chromen-2-One is a high-purity, advanced pharmaceutical intermediate featuring a coumarin core functionalized with a pinacol boronate ester group. This compound is a critical building block in modern organic synthesis, enabling key carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex coumarin derivatives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the coumarin-boronate structure imparts specific biological activity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of advanced organic electronic materials, such as OLEDs and sensors.
• Organic Synthesis: An essential reagent for Suzuki-Miyaura cross-coupling reactions, facilitating the efficient construction of biaryl and heterobiaryl systems in complex molecule assembly.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag due to its boronate functionality, which can be used for selective labeling or as a handle for further bioconjugation.

Basic Information

Product Name	6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Chromen-2-One
CAS No.	1408287-07-9
Molecular Formula	C15H17BO4
Molecular Weight	272.11 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-chromen-2-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)coumarin; 6-Coumarinboronic Acid Pinacol Ester; 6-Pinacolatoborylcoumarin; 2-Oxo-2H-chromene-6-boronic Acid Pinacol Ester; 6-Boronocoumarin Pinacol Ester; 6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Chromen-2-One
EINECS	Contact for details

Quality Control

Our 6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Chromen-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.