Description

Ethyl 2-(cis-3-Hydroxycyclobutyl)Acetate is a high-value, functionalized cyclobutane derivative that serves as a versatile chiral building block in advanced organic synthesis. Its unique cis-configured hydroxycyclobutyl structure makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, including protease inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclobutane ring contributes to unique biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemical configurations.
• Material Science Research: Investigated as a monomer or building block for novel polymers with tailored physical properties.
• Academic & R&D: A valuable tool in synthetic organic chemistry research for method development and exploring new chemical spaces.

Basic Information

Product Name	Ethyl 2-(cis-3-Hydroxycyclobutyl)Acetate
CAS No.	1408075-71-7
Molecular Formula	C8H14O3
Molecular Weight	158.20 g/mol
Synonyms	Ethyl (cis-3-hydroxycyclobutyl)acetate; Acetic acid, 2-(cis-3-hydroxycyclobutyl)-, ethyl ester; cis-3-Hydroxycyclobutylacetic acid ethyl ester; Ethyl cis-3-hydroxycyclobutaneacetate; 2-((1r,3s)-3-Hydroxycyclobutyl)ethyl acetate; (1r,3s)-3-(2-Ethoxy-2-oxoethyl)cyclobutanol
EINECS	Contact for details

Quality Control

Our Ethyl 2-(cis-3-Hydroxycyclobutyl)Acetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.