Description

1-Boc-3-(Methylaminomethyl)-3-Fluoroazetidine is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated azetidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical companies and R&D laboratories focused on developing new therapeutics, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting protein-protein interactions.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation platforms.
• CNS Drug Discovery: The fluorinated azetidine core is valuable for creating molecules designed to cross the blood-brain barrier.
• Chemical Biology Probes: Utilized in the development of selective chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-Boc-3-(Methylaminomethyl)-3-Fluoroazetidine
CAS No.	1408074-60-1
Molecular Formula	C10H19FN2O2
Molecular Weight	218.27 g/mol
Synonyms	1-Boc-3-(Methylaminomethyl)-3-fluoroazetidine; tert-Butyl 3-(methylaminomethyl)-3-fluoroazetidine-1-carboxylate; 3-Fluoro-3-[(methylamino)methyl]-1-azetidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-(methylaminomethyl)-3-fluoroazetidine; N-Boc-3-(Methylaminomethyl)-3-fluoroazetidine; Boc-3-Fluoro-3-(methylaminomethyl)azetidine; 1408074-60-1
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(Methylaminomethyl)-3-Fluoroazetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.