Description

Ethyl trans-3-Hydroxy-1-Methyl-Cyclobutanecarboxylate is a high-purity, functionalized cyclobutane derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its ability to introduce a defined stereochemistry and a protected hydroxyl group into complex molecular frameworks, enabling the efficient production of high-value target molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where precise stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fragrance and Flavor Chemistry: Employed as a building block for synthesizing complex, stereochemically defined aroma chemicals.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with unique cyclic structures and properties.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and total synthesis projects.

Basic Information

Product Name	Ethyl trans-3-Hydroxy-1-Methyl-Cyclobutanecarboxylate
CAS No.	1408074-59-8
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	Ethyl (1R,3S)-3-Hydroxy-1-methylcyclobutanecarboxylate; trans-Ethyl 3-hydroxy-1-methylcyclobutanecarboxylate; 1-Methyl-3-hydroxycyclobutanecarboxylic acid ethyl ester; (1R,3S)-1-Methyl-3-hydroxycyclobutanecarboxylic acid ethyl ester; Cyclobutanecarboxylic acid, 3-hydroxy-1-methyl-, ethyl ester, trans-; Ethyl 1-methyl-3-hydroxycyclobutanecarboxylate; 1408074-59-8
EINECS	Contact for details

Quality Control

Our Ethyl trans-3-Hydroxy-1-Methyl-Cyclobutanecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and GC, to ensure identity, purity, and enantiomeric excess meet stringent specifications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.