Description

(R)-3,3-Difluoro-Cyclopentanemethanamine CAS NO 1408057-42-0 is a chiral, fluorinated amine building block of significant interest in modern synthetic chemistry. Its value lies in the unique combination of a constrained cyclopentane scaffold and fluorine atoms, which are critical for modulating the physicochemical and metabolic properties of bioactive molecules. This compound is primarily needed by pharmaceutical and agrochemical research organizations for the development of new active ingredients, where it serves as a key intermediate in the synthesis of complex, stereochemically defined targets.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the fluorine atoms and amine functionality contribute to enhanced biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science: Potential building block for specialty polymers and advanced materials where fluorine incorporation is desired for specific properties like chemical resistance or low surface energy.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes and labeled compounds for studying biological mechanisms and diagnostic applications.

Basic Information

Product Name	(R)-3,3-Difluoro-Cyclopentanemethanamine
CAS No.	1408057-42-0
Molecular Formula	C6H11F2N
Molecular Weight	135.16 g/mol
Synonyms	(1R)-3,3-Difluorocyclopentylmethanamine; (R)-3,3-Difluorocyclopentylmethylamine; (R)-3,3-Difluorocyclopentanemethylamine; (R)-1-(Aminomethyl)-3,3-difluorocyclopentane; (R)-α,α-Difluorocyclopentane methylamine; (R)-3,3-Difluoro-1-cyclopentanemethanamine; (R)-3,3-Difluorocyclopentane-1-methanamine
EINECS	Contact for details

Quality Control

Our (R)-3,3-Difluoro-Cyclopentanemethanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (Assay by GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.