Description

(R)-3,3-Difluoro-Cyclopentanemethanol is a chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a stereodefined cyclopentane scaffold with difluoromethylene and hydroxymethyl functional groups, enabling precise modulation of molecular properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where its fluorine atoms can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and metabolic disease therapeutics.
• Agrochemical Synthesis: Used in the design and synthesis of advanced pesticides and herbicides, where the fluorinated cyclopentane structure can contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Investigated as a monomer or modifier for creating specialty polymers with tailored thermal and chemical resistance properties.
• Fluorine Chemistry Studies: Employed as a model compound in academic and industrial research to study the effects of gem-difluoro substitution on conformation and reactivity.
• Peptidomimetics & Bioisosteres: The difluorocyclopentane moiety is used to replace traditional peptide bonds or cyclic structures in drug design to improve pharmacokinetic properties.

Basic Information

Product Name	(R)-3,3-Difluoro-Cyclopentanemethanol
CAS No.	1407997-85-6
Molecular Formula	C6H10F2O
Molecular Weight	136.14 g/mol
Synonyms	(R)-3,3-Difluorocyclopentylmethanol; (1R)-3,3-Difluorocyclopentylmethanol; (R)-3,3-Difluorocyclopentanemethanol; (R)-3,3-Difluorocyclopentylcarbinol; (R)-3,3-Difluoro-1-cyclopentanemethanol; (R)-3,3-Difluorocyclopentane-1-methanol; (R)-3,3-Difluorocyclopentylmethyl alcohol; (R)-3,3-Difluorocyclopentyl methanol
EINECS	Contact for details

Quality Control

Every batch of (R)-3,3-Difluoro-Cyclopentanemethanol undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of cGMP and ISO 9001 standards for fine chemical manufacturing. Comprehensive Certificates of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain optimal quality. Keep away from strong bases and fluorinating agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.