Description

1H-Indole, 2,3-Dihydro-1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, synthetically versatile boronic ester derivative of a substituted indoline, serving as a critical building block in modern organic synthesis. Its primary commercial value lies in its role as a key intermediate for constructing complex molecules via palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing complex heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific indoline-based structures.
• Material Science Research: Employed as a monomer or building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for coupling with aryl or vinyl halides to form new carbon-carbon bonds.
• Medicinal Chemistry & Drug Discovery: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies in lead optimization campaigns.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Indole, 2,3-Dihydro-1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1404110-01-5
Molecular Formula	C15H22BNO2
Molecular Weight	259.15 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-2,3-dihydro-1H-indole; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline; 1-Methylindoline-6-boronic acid pinacol ester; 6-Borono-1-methylindoline pinacol ester; 1-Methyl-2,3-dihydro-1H-indole-6-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 1H-Indole, 2,3-Dihydro-1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. Our quality assurance protocols include advanced chromatographic and spectroscopic methods to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing purity (typically >95% by HPLC), residual solvent levels, and other critical parameters is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize moisture uptake. Optimal storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.