Description

1-Ethynyl-2-Fluoro-3-Methoxybenzene is a specialized aromatic building block featuring a unique combination of an ethynyl group, a fluorine atom, and a methoxy substituent. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of complex molecules for pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atom and ethynyl group can enhance biological activity and stability.
• Material Science: Serves as a monomer or precursor in the development of advanced polymers and functional materials with specific electronic or optical properties.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions to form conjugated systems.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: Acts as a model compound in research exploring the effects of fluorine substitution on aromatic reactivity and physical properties.

Basic Information

Product Name	1-Ethynyl-2-Fluoro-3-Methoxybenzene
CAS No.	1402353-80-3
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	2-Fluoro-3-methoxyphenylacetylene; 2-Fluoro-3-methoxyethynylbenzene; 1-Ethynyl-2-fluoro-3-methoxy-benzene; 3-Methoxy-2-fluorophenylacetylene; (2-Fluoro-3-methoxyphenyl)ethyne; 2-Fluoro-3-methoxyphenylethyne; 2-Fluoro-3-methoxy-1-ethynylbenzene
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-2-Fluoro-3-Methoxybenzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids, oxidizing agents, and sources of ignition. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.