Description

2-(4-Methylimidazol-1-Yl)Pyrimidine-5-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and key building block in modern organic synthesis. Its value lies in its role as a versatile boronic ester derivative, enabling critical carbon-carbon bond formation reactions like the Suzuki-Miyaura cross-coupling. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds between aryl/heteroaryl groups, a cornerstone reaction in medicinal and process chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(4-Methylimidazol-1-Yl)Pyrimidine-5-Boronic Acid, Pinacol Ester
CAS No.	1402240-42-9
Molecular Formula	C14H19BN4O2
Molecular Weight	286.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-methyl-1H-imidazol-1-yl)pyrimidine; 2-(4-Methyl-1H-imidazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(4-Methylimidazol-1-yl)pyrimidine-5-boronic acid pinacol ester; 1402240-42-9; 2-(4-Methyl-1H-imidazol-1-yl)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(4-Methylimidazol-1-Yl)Pyrimidine-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.