Description

2-Difluoromethoxy-6-Methylpyridine-4-Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative, essential for modern cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex heterocyclic scaffolds, which are critical in advanced material and pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for synthesizing novel active ingredients and functional molecules. CAS No. 1402238-41-8.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, particularly those containing difluoromethoxy and pyridine motifs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the introduction of specific fluorinated heterocycles can enhance biological activity and stability.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems, leveraging the boronic ester's reactivity for bioconjugation.
• Process Chemistry & Scale-up: The pinacol ester protection offers improved stability and handling properties, making it suitable for process optimization and larger-scale synthesis campaigns.

Basic Information

Product Name	2-Difluoromethoxy-6-Methylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	1402238-41-8
Molecular Formula	C14H18BF2NO3
Molecular Weight	297.11 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[6-methyl-2-(difluoromethoxy)pyridin-4-yl]-1,3,2-dioxaborolane; 2-(Difluoromethoxy)-6-methylpyridine-4-boronic acid pinacol ester; 6-Methyl-2-(difluoromethoxy)pyridine-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methyl-2-(difluoromethoxy)pyridine; Pinacol 2-(Difluoromethoxy)-6-methylpyridine-4-boronate; Boronic acid, B-[2-(difluoromethoxy)-6-methyl-4-pyridinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-6-Methylpyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay (HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical R&D and other advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.