Description

Methyl 2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex biaryl and heterobiaryl structures in modern organic synthesis. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing biphenyl or substituted aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aromatic architectures.
• Material Science Research: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular structure is critical.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, enzyme inhibitors, and bioconjugation reagents leveraging boronate chemistry.
• Academic & Industrial R&D: A versatile reagent for method development and exploring new synthetic pathways in organic chemistry laboratories worldwide.
• Custom Synthesis & Contract Manufacturing: Supplied as a high-purity starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	Methyl 2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1402238-34-9
Molecular Formula	C14H18BNO6
Molecular Weight	307.11 g/mol
Synonyms	2-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 2-nitro-4-(pinacolatoboron)benzoate; 4-Pinacolatoboron-2-nitrobenzoic acid methyl ester; 2-Nitro-4-(pinacolboronato)benzoic acid methyl ester; Benzoic acid, 2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 4-(pinacolatoboron)-2-nitrobenzoate; PINACOL 2-NITRO-4-CARBOMETHOXYPHENYLBORONATE
EINECS	Contact for details

Quality Control

Our Methyl 2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.