Description

2-(4-(Bromomethyl)-3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing complex biaryl and heterobiaryl structures with high efficiency and selectivity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific chlorinated and brominated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes due to its versatile coupling handle.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-(4-(Bromomethyl)-3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1402238-25-8
Molecular Formula	C13H17BBrClO2
Molecular Weight	334.44 g/mol
Synonyms	(4-(Bromomethyl)-3-chlorophenyl)boronic acid pinacol ester; 3-Chloro-4-(bromomethyl)phenylboronic acid pinacol ester; 1-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(bromomethyl)benzene; Pinacol [3-chloro-4-(bromomethyl)phenyl]boronate; 2-(3-Chloro-4-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1402238-25-8
EINECS	Contact for details

Quality Control

Every batch of our 2-(4-(Bromomethyl)-3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is produced and tested under strict quality management protocols to ensure high purity, lot-to-lot consistency, and reliable performance in sensitive coupling reactions. Our products undergo rigorous quality testing, including HPLC, NMR, and elemental analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature: 2-8°C (refrigerated) or as indicated on the label.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.