Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(3-(Trifluoromethyl)Phenyl)Thiazole is a high-value organoboron building block, specifically a pinacol boronate ester, essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for the development of novel active ingredients and functional materials, particularly those requiring the incorporation of the trifluoromethylphenyl-thiazole pharmacophore.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for coupling with various aryl/heteroaryl halides to form biaryl and heterobiaryl structures.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biological target identification and validation.
• Ligand Synthesis for Catalysis: Acts as a precursor for synthesizing complex ligands used in homogeneous catalysis.

Basic Information

Item	Detail
Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(3-(Trifluoromethyl)Phenyl)Thiazole
CAS No.	1402237-78-8
Molecular Formula	C16H19BF3NO2S
Molecular Weight	357.20 g/mol
Synonyms	2-(3-(Trifluoromethyl)phenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole; 2-(3-Trifluoromethylphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4,4,5,5-Tetramethyl-2-[2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl]-1,3,2-dioxaborolane; (2-(3-(Trifluoromethyl)phenyl)thiazol-4-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(3-(Trifluoromethyl)Phenyl)Thiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.