Description

2-(4-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole is a high-value boronic ester derivative, a key intermediate in modern synthetic chemistry. Its primary commercial value lies in its role as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and advanced functional materials. The CAS number for this product is 1402227-63-7.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing thiazole and biphenyl motifs with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-thiazole architectures.
• Material Science & OLED Development: Serves as a building block for creating organic light-emitting diode (OLED) materials, electronic chemicals, and liquid crystals due to its electron-transporting thiazole core and modifiable structure.
• Academic & Contract Research: A valuable reagent for synthetic organic chemists in academia and CROs (Contract Research Organizations) exploring new catalytic methodologies and complex molecule synthesis.
• Polymer Chemistry: Can be incorporated into polymer backbones via cross-coupling to create specialty polymers with tailored electronic or optical properties.

Basic Information

Product Name	2-(4-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
CAS No.	1402227-63-7
Molecular Formula	C16H20BNO3S
Molecular Weight	317.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-methoxyphenyl)thiazole; 2-(4-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)thiazole; 4-Methoxyphenyl-5-(pinacolboron)thiazole; 2-(4-Methoxyphenyl)thiazole-5-boronic acid pinacol ester; Thiazole boronic ester, 2-(4-methoxyphenyl)-5-; Pinacol [2-(4-methoxyphenyl)-1,3-thiazol-5-yl]boronate
EINECS	Contact for details

Quality Control

Every batch of our 2-(4-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR (¹H and ¹³C), and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is between 2°C and 8°C (refrigerated) to maximize shelf-life and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.