Description

2-(2-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound matters for its role as a key precursor in cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing thiazole and biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds, essential in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Organic Light-Emitting Diodes (OLEDs): Acts as a precursor for electron-transport or emissive layer materials in advanced display technologies.
• Ligand Synthesis for Catalysis: Employed in the preparation of novel ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	2-(2-Methoxyphenyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazole
CAS No.	1402227-61-5
Molecular Formula	C16H20BNO3S
Molecular Weight	317.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-methoxyphenyl)thiazole; 2-(2-Methoxyphenyl)thiazole-5-boronic acid pinacol ester; 2-(o-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2-(2-Methoxyphenyl)-5-(pinacolboranyl)thiazole; 1402227-61-5; Thiazole boronic ester derivative; B-(2-(2-Methoxyphenyl)thiazol-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2-Methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.