Description

2-(2-Fluorophenyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is a high-value, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry and drug discovery. Its primary value lies in the boronic ester functional group, which enables efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern C-C bond formation. Professionals in pharmaceutical R&D, agrochemical development, and material science rely on this high-purity intermediate to accelerate their synthesis of complex, fluorinated heterocyclic target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those containing fluorinated thiazole motifs for improved metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds to attach complex aryl groups, essential for constructing diverse chemical libraries in drug discovery.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine atom and thiazole ring can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functional unit in the development of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized to create labeled compounds or probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-(2-Fluorophenyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole
CAS No.	1402174-42-8
Molecular Formula	C15H17BFNO2S
Molecular Weight	305.18 g/mol
Synonyms	2-(2-Fluorophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-fluorophenyl)thiazole; 2-(2-Fluorophenyl)thiazole-4-boronic acid pinacol ester; 2-(2-Fluorophenyl)-4-(pinacolboron)thiazole; 1402174-42-8; 2-(2-Fluorophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Fluorophenyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive characterization via NMR, HPLC, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.