Description

5-Amino-6-Bromopyrazine-2-Boronic Acid Pinacol Ester is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a reactive boronic ester group and a halogenated, aminated pyrazine core, enabling efficient cross-coupling and further functionalization. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, particularly in drug discovery and catalyst development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functionality makes it an ideal partner for palladium-catalyzed cross-coupling to form carbon-carbon bonds, a cornerstone of medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organometallic catalysts.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors for OLEDs and OFETs.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	5-Amino-6-Bromopyrazine-2-Boronic Acid Pinacol Ester
CAS No.	1402172-88-6
Molecular Formula	C10H15BBrN3O2
Molecular Weight	300.97 g/mol
Synonyms	5-Amino-6-bromopyrazin-2-ylboronic acid pinacol ester; (5-Amino-6-bromopyrazin-2-yl)boronic acid pinacol ester; 2-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-3-amine; 6-Bromo-5-aminopyrazine-2-boronic acid pinacol ester; 1402172-88-6; 5-Amino-6-bromo-2-pyrazineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-6-Bromopyrazine-2-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, NMR confirmation, and other critical parameters is provided with each shipment to guarantee traceability and reliability for your sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.