Description

4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Yl)Morpholine is a high-value, advanced pharmaceutical intermediate featuring a unique thiazole-morpholine scaffold with a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel drug candidates and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for carbon-carbon bond formation in the development of complex heterocyclic compounds.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug-like properties.
• Agrochemical Development: Intermediate in the creation of novel pesticides and herbicides with enhanced efficacy.
• Material Science: Precursor for organic electronic materials and functional polymers requiring specific molecular architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Yl)Morpholine
CAS No.	1402172-49-9
Molecular Formula	C₁₃H₂₁BN₂O₃S
Molecular Weight	296.19 g/mol
Synonyms	4-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazol-2-yl]morpholine; 2-Morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4-(5-(Pinacolatoboryl)thiazol-2-yl)morpholine; 1402172-49-9; Thiazole boronic acid pinacol ester morpholine derivative; Morpholine, 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thiazolyl]-
EINECS	Contact for details

Quality Control

Our 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Yl)Morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency suitable for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.