Description

2-(Tetrahydro-2H-Pyran-4-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and antiviral research.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds between pyrimidine rings and various aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Proteomics: Acts as a valuable tool compound for bioconjugation and the development of chemical probes.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries for biological evaluation in drug discovery programs.

Basic Information

Product Name	2-(Tetrahydro-2H-Pyran-4-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1402166-38-4
Molecular Formula	C15H23BN2O3
Molecular Weight	290.17 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)pyrimidine; 2-(Oxan-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-THP-5-BPin-Pyrimidine; 2-(Tetrahydropyran-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; CAS 1402166-38-4; Pyrimidine, 2-(tetrahydro-2H-pyran-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-(Tetrahydro-2H-Pyran-4-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent degradation due to moisture sensitivity and oxidation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.