Description

1-Chloro-2-Fluoro-3-Iodo-4-Methoxybenzene is a highly functionalized, multi-halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique substitution pattern, which provides multiple orthogonal reactive sites for selective chemical transformations. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting complex heterocycles and fluorinated bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the halogen and methoxy groups contribute to biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals, leveraging its aromatic core and halogen substituents.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution due to the reactive iodine and fluorine atoms.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in related chemical processes.

Basic Information

Product Name	1-Chloro-2-Fluoro-3-Iodo-4-Methoxybenzene
CAS No.	1402004-77-6
Molecular Formula	C7H5ClFIO
Molecular Weight	286.47 g/mol
Synonyms	4-Methoxy-1-chloro-2-fluoro-3-iodobenzene; 3-Iodo-4-methoxy-1-chloro-2-fluorobenzene; 2-Fluoro-3-iodo-4-methoxychlorobenzene; 1-Chloro-2-fluoro-3-iodo-4-methoxy-benzene; Benzene, 1-chloro-2-fluoro-3-iodo-4-methoxy-; 4-Methoxy-2-fluoro-3-iodochlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Fluoro-3-Iodo-4-Methoxybenzene is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.