Description

Methyl 6-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is a high-value, advanced pharmaceutical intermediate featuring a picolinate ester core functionalized with a pinacol boronate ester group. This compound matters as a critical building block in modern synthetic chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions to construct complex heterocyclic scaffolds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing biphenyl or aryl-heteroaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with complex molecular structures.
• Material Science: Potential precursor for creating organic electronic materials and ligands for catalysis.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes and tool compounds for target validation and drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds at various scales, from milligrams to kilograms.

Basic Information

Product Name	Methyl 6-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate
CAS No.	1402004-07-2
Molecular Formula	C14H20BNO5
Molecular Weight	293.12 g/mol
Synonyms	Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methoxypicolinate; 6-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid methyl ester; 5-Borono-6-methoxypicolinic acid methyl ester, pinacol ester; Methyl 6-methoxy-5-(pinacolatoboryl)picolinate; 1402004-07-2; Methyl 5-(pinacolatoboryl)-6-methoxypicolinate; Pinacol [6-(methoxycarbonyl)-2-methoxypyridin-3-yl]boronate
EINECS	Contact for details

Quality Control

Our Methyl 6-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.