Description

(2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester group. This compound is essential for modern synthetic chemistry, particularly in the construction of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to introduce functionalized aromatic fragments with precision.

Application

• Key Intermediate in API Synthesis: Serves as a critical building block for active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety enables efficient, palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides and fungicides that require specific aromatic substitution patterns.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and material science.
• Polymer and Advanced Material Chemistry: Incorporated into monomers for producing specialty polymers with tailored electronic or mechanical properties.
• Chemical Biology and Probe Development: Utilized to create molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	(2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol
CAS No.	1400755-05-6
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	[3-(Hydroxymethyl)-2-methylphenyl]boronic acid pinacol ester; 2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol; (3-(Hydroxymethyl)-2-methylphenyl)boronic acid pinacol ester; Pinacol [3-(hydroxymethyl)-2-methylphenyl]boronate; 2-Methyl-3-(pinacolatoboryl)benzyl alcohol; Boronic acid, B-[3-(hydroxymethyl)-2-methylphenyl]-, pinacol ester; CAS 1400755-05-6
EINECS	Contact for details

Quality Control

Every batch of (2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.